Powerlifter in red shirt preparing to perform heavy, muscle damaging squats

Squats, Muscle Damage and Recovery

Some closing thoughts on Monday's post for you where we talked about squats, muscle damage and recovery.

The time curve of voluntary muscle activation recovery following a workout and muscle soreness are not the same. Voluntary activation drops right after a damaging and depleting workout and recovers slowly over a couple of days. Muscle soreness, however, usually peaks a 1-2 days post-workout and can last for approximately a week. 

So, it might be that it is the inflammatory response triggered by the workout that causes CNS fatigue since they follow a similar time course.

Workout = inflammatory response = CNS fatigue

In the squat study, CNS fatigue was similar in all three groups however, muscle damage indices were greatest in the untrained group. Which is nothing new.

Past research has shown that new lifters experience greater muscle damage than experienced lifters.  As lifters become adapted to training over time (repeated bout effect) the amount of inflammation that is caused by a given level of muscle damage increases. Therefore, the build-up of CNS fatigue for a given level of muscle damage is typically greater for trained individuals.

So, new lifters tend to experience greater muscle damage from a given workout. More experienced lifters gather more CNS fatigue. 

Being matched for both training status and volume and the lack of difference in CNS fatigue between the groups, it’s possible that the slower strength recovery in the middle-aged group might come down to muscle damage and a slower muscle repair rate. 

Ultimately, the link between CNS fatigue and muscle damage is still not clear with some conflicting evidence. 

And so the search for the perfect program continues…


1. CNS (central nervous system) fatigue was measured by voluntary activation during a maximal voluntary isometric muscle contraction (MVIC). 

2. Voluntary activation (VA) is the level of neural drive from the central nervous system to produce a given force output from a muscle.


  1. Exercise-Induced Muscle Damage and Recovery in Young and Middle-Aged Males with Different Resistance Training Experience. Fernandes, et al. 2019

About Danny James

Danny James is a Strength and Conditioning Coach and Personal Trainer in Sydney, Australia with over 15 years of experience supporting national champions and international representatives to reach higher levels of performance and well-being in multiple sports. He lives with his beautiful wife and twins. Sign up for Danny's free newsletter and receive tips, insights, and exclusive email-only content.


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